Journal Papers

This page provides links to studies evaluating approaches to lung cancer screening, including two key projects: the US National Lung Screening Trial and the Dutch-Belgian NELSON study.

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Early detection for lung cancer. New tools for casefinding

Author: Lam et al. Publication Source: Canadian Family Physician Country: Canada Date: March 2001 Summary of Content: This study reviews data from published population trials and clinical practice guidelines to support the introduction of lung cancer screening. Link to Document: https://www.cfp.ca/content/47/3/537.long

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Results of the Randomized Danish Lung Cancer Screening Trial with Focus on High-Risk Profiling

Author: Wille et al. Publication Source: American Journal of Respiratory and Critical Care Medicine Country: March 2016 Date: N/A Summary of Content: This study reports the findings of the Danish Lung Cancer Screening Trial five years after the last screening round. Link to Document: https://www.atsjournals.org/doi/abs/10.1164/rccm.201505-1040OC

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Mortality, survival and incidence rates in the ITALUNG randomised lung cancer screening trial

Author: Paci et al. Publication Source: British Medical Journal Country: Europe Date: September 2017 Summary of Content: This study evaluates the effectiveness of lung cancer screening to reduce mortality in Italy, and is contributing to the European evaluation of screening. Link to Document: https://thorax.bmj.com/content/72/9/825.long (Access Required)

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Prolonged lung cancer screening reduced 10-year mortality in the MILD trial: new confirmation of lung cancer screening efficacy

Author: Pastorino et al. Publication Source: Annals of Oncology Country: Europe Date: July 2019 Summary of Content: This study evaluates the benefits of lung cancer screening beyond five years and its impact on mortality after 10 years. Link to Document: https://academic.oup.com/annonc/article/30/7/1162/5425325

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Lung cancer mortality reduction by LDCT screening—Results from the randomized German LUSI trial

Author: Becker et al. Publication Source: International Journal of Cancer Country: Europe Date: June 2019 Summary of Content: This study analyses data from a German lung cancer screening trial which compared five annual rounds of lung cancer screening. Link to Document: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32486 (Access Required)

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Final screening round of the NELSON lung cancer screening trial: the effect of a 2.5-year screening interval

Author: Yousaf-Khan et al. Publication Source: British Medical Journal Country: Europe Date: December 2016 Summary of Content: This study reports findings of the fourth round of screening in the European NELSON trial, which took place 2.5 years after the initial three screening rounds. Link to Document: https://thorax.bmj.com/content/thoraxjnl/72/1/48.full.pdf

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The Cost-Effectiveness of Low-Dose CT Screening for Lung Cancer

Author: Wisnivesky Publication Source: Chest Journal Country: USA Date: August 2003 Summary of Content: This study evaluates the cost-effectiveness of lung cancer screening in high risk individuals compared to those who have not been screened. Link to Document: https://journal.chestnet.org/article/S0012-3692(15)33347-X/pdf (Access Required)

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Reduced lung-cancer mortality with low-dose computed tomographic screening

Author: National Lung Screening Trial Research Team Publication Source: The New England Journal of Medicine Country: USA Date: August 2011 Summary of Content: This study provides an overview of the National Lung Screening Trial and supports the implementation of lung cancer screening. Link to Document: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356534/

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Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement.

Author: Moyer et al. Publication Source: Annals of Internal Medicine Country: USA Date: March 2014 Summary of Content: This resource provides an overview of the evidence in support for lung cancer screening, the optimum age at which to begin screening, screening intervals and the benefits and harms of different screening strategies. Link to Document: https://annals.org/aim/fullarticle/1809422/screening-lung-cancer-u-s-preventive-services-task-force-recommendation

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Update on screening for lung cancer

Author: Moyer et al. Publication Source: Annals of Internal Medicine Country: USA Date: March 2014 Summary of Content: This resource provides an overview of the evidence in support for lung cancer screening, the optimum age at which to begin screening, screening intervals and the benefits and harms of different screening strategies. Link to Document: https://annals.org/aim/fullarticle/1809422/screening-lung-cancer-u-s-preventive-services-task-force-recommendation

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Implementing lung cancer screening: baseline results from a community-based ‘Lung Health Check’ pilot in deprived areas of Manchester.

Author: Crosbie et al. Publication Source: British Medical Journal Country: UK Date: February 2018 Summary of Content: This study presents the baseline findings of a community-based, targeted lung cancer screening pilot in deprived areas of Manchester. Link to Document: https://thorax.bmj.com/content/74/4/405.long (Access Required)

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Second round results from the Manchester ‘Lung Health Check’ community-based targeted lung cancer screening pilot

Author: Crosbie et al. Publication Source: British Medical Journal Country: UK Date: November 2018 Summary of Content: The study presents the results from the second annual screening round of a community-based, targeted lung cancer screening pilot in deprived areas of Manchester. Link to Document: https://thorax.bmj.com/content/thoraxjnl/74/7/700.full.pdf

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The cost-effectiveness of the Manchester ‘lung health checks’, a community-based lung cancer low-dose CT screening pilot

Author: Hinde et al. Publication Source: Lung Cancer Country: UK Date: December 2018 Summary of Content: This study applies Manchester, UK, specific evidence to estimate the cost effectiveness of lung cancer screening. Link to Document: https://www.lungcancerjournal.info/article/S0169-5002(18)30627-5/fulltext (Access Required)

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Effects of low-dose computed tomography on lung cancer screening: a systematic review, meta-analysis, and trial sequential analysis

Author: Huang et al. Publication Source: BMC Pulmonary Medicine Country: UK Date: July 2019 Summary of Content: This study reviews previous evidence and considers the benefits and harms of lung cancer screening. Link to Document: https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-019-0883-x#Sec13

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The UK Lung Cancer Screening Trial: a pilot randomised controlled trial of low-dose computed tomography screening for the early detection of lung cancer.

Author: Field et al. Publication Source: Health Technology Assessment Country: UK Date: May 2016 Summary of Content:  This study analyses lung cancer screening in a high-risk population in the UK to determine the best recruitment, screening, reading and care pathway strategies; and assesses the psychological consequences and health economic implications of screening. Link to Document:  https://www.ncbi.nlm.nih.gov/pubmed/27224642

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Participant Selection For Lung Cancer Screening By Risk Modelling (The Pan-Canadian Early Detection of Lung Cancer Study)

Author: Tammemagi et al. Publication Source: Lancet Oncology Country: Canada Date: October 2017 Summary of Content: This study assesses the effectiveness of a risk prediction model to select people with early lung cancer for screening in Canada. Link to Document: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(17)30597-1/fulltext

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A Blueprint For Screening

Author: Wender RC, Brawley OW, Fedewa SA, Gansler T, Smith RA. Publication Source: CA Cancer Journal Country: USA Date: 2019 Summary of Content: This study reviews and evaluates advancing screening’s contribution to cancer control Link to Document:  https://nlcrt.org/resource/a-blueprint-for-cancer-screening-and-early-detection-advancing-screenings-contribution-to-cancer-control/

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The Role of Lung Advocacy Organizations in Biomarker Testing

Author: Carolyn Aldigé, Upal Basu Roy, Win Boerckel et al Publication Source: Cancer Care white paper Country: USA Date: August 2018 Summary of Content: This white paper aims to highlight advances in lung cancer treatment due to the advent of targeted therapies, describe underutilization of biomarker testing in patients with advanced lung cancer, and develop an action plan to optimize the […]

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Lung Cancer Screening Implementation: Complexities And Priorities

Author: Rankin et al. Publication source: Official Journal of the Asian Pacific Society of Respirology Country: n/a Date of publication: November 2020 Summary of content: This study considers the key issues that influence lung cancer screening uptake and the programme elements needed to maximise the impact of lung cancer screening. Link to document:  https://onlinelibrary.wiley.com/doi/full/10.1111/resp.13963?campaign=woletoc

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